Sexual Dimorphic Regulation of Liver Gene Expression by Glucocorticoids

ABSTRACT: Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory hormone in all mammals and synthetic derivatives of these hormones are widely prescribed as anti-inflammatory agents irrespective of gender. Surprisingly we report a marked sexually dimorphic regulation of gene expression by glucocorticoids in the rat liver. Eight distinct patterns of glucocorticoid regulated genes were identified and two revealed genes that respond to glucocorticoid treatment in both sexes in opposite directions (anti-correlated genes. We also identified gender-specific groups of g

ORGANISM(S): Rattus norvegicus

SUBMITTER: NIEHS Microarray Core 

PROVIDER: E-GEOD-13461 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress