Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Johan Skog
PROVIDER: E-GEOD-13470 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature cell biology 20081116 12
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate that messages delivered by microvesicles are translated by recipient cells. These microvesicles are also enriched in angiogenic proteins and stimulate tubule formation by endothelial cells. Tumour-deriv ...[more]