Transcription profiling by array of human normal pre-frontal cortex, liver, and colon tissues and colon tumors

ABSTRACT: DNA methylation, at CpG islands and promoters, is often inversely correlated with gene expression. We used expression microarrays to determine the relationship between DNA methylation and gene expression in 5 normal prefrontal cortex samples and 5 normal liver samples from the same individuals as well as between 4 colon tumor and matched normal colon mucosa (from the same individuals). Experiment Overall Design: We isolated RNA from pre-frontal cortex and liver tissue from 5 individuals for which we have genome-wide DNA methylation data and hybridized to Affymetrix gene expression microarrays. Similarly, we isolated RNA from 4 tumor and matched normal colon samples that we have genome-wide DNA methylation data..

This experiment was reloaded in November 2010 after additional curation

ORGANISM(S): Homo sapiens

SUBMITTER: rafael irizarry 

PROVIDER: E-GEOD-13471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress