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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human MCF7 cells treated with ARC (NSC 188491)

ABSTRACT: ARC (NSC 188491, SMA-491), 4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2,3-d)-pyrimidine-5-carboxamide, is a nucleoside analog with profound in vitro anti-cancer activity. First identified in a high-throughput screen for inhibitors of p21 mRNA expression, subsequent experiments showed that ARC also repressed expression of hdm2 and survivin, leading to its classification as a global inhibitor of transcription 1. The following Hu U133 plus 2.0 arrays represent single time point (24 hour) gene expression analysis of transcripts altered by ARC treatment. Arrays for the other compounds (sangivamycin and doxorubicin) are included as comparators. Experiment Overall Design: MCF7 cells treated with ARC, Sangivamycin or Doxorubicin for 24 hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Luke Hunter Stockwin

PROVIDER: E-GEOD-13477 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene Expression Analysis of ARC (NSC 188491) Treated MCF7 cells

Project description:ARC (NSC 188491, SMA-491), 4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2,3-d)-pyrimidine-5-carboxamide, is a nucleoside analog with profound in vitro anti-cancer activity. First identified in a high-throughput screen for inhibitors of p21 mRNA expression, subsequent experiments showed that ARC also repressed expression of hdm2 and survivin, leading to its classification as a global inhibitor of transcription 1. The following Hu U133 plus 2.0 arrays represent single time point (24 hour) gene expression analysis of transcripts altered by ARC treatment. Arrays for the other compounds (sangivamycin and doxorubicin) are included as comparators.

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High-resolution mapping of regulatory element interactions and genome architecture using ARC-C [ARC-C]

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Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo

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ARC-SSMS-green-tea-metabolomics

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2023-02-09 | MSV000091238 | MassIVE

Arc/Arg3.1 functionally defines migrating 1 dendritic cells and regulates actin dynamics

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2015-08-12 | E-GEOD-71937 | biostudies-arrayexpress

The 3’UTR of ArgR regulates the arc operon

Project description:ArgR and the sRNA from its 3’UTR, ArgX, both regulate the arc operon by influencing transcription and RNA stability/translation respectively

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ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.

Project description: Not available

| S-EPMC2651907 | biostudies-literature

Identification of genes enriched in the Arc, VMH, DMH and LH of adult mouse

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