Halobacterium salinarum NRC-1 VNG1451C transcription factor ChIP-chip with and without carbon sources

ABSTRACT: Gene regulatory networks play an important role in coordinating biochemical fluxes through diverse metabolic pathways. The modulation of enzyme levels enables efficient utilization of limited resources as organisms dynamically acclimate to nutritional fluctuations in their environment. Here we have identified and characterized a novel nutrient-responsive transcription factor from the halophilic archaea, AgmR. Like TrmB, its thermophilic archaeal homolog, AgmR regulates glycolytic and gluconeogenic pathways in response to sugar availability. However, using high throughput genome-scale experiments, we find that AgmR directly governs the transcription of nearly 100 additional genes encoding enzymes in diverse metabolic pathways. Genome-scale in vivo binding site location data reveals that >

ORGANISM(S): Halobacterium sp. NRC-1

SUBMITTER: Baliga Nitin S. 

PROVIDER: E-GEOD-13498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress