Predective Value of Prognosis-Related Gene Expression Study in Primary Bladder Cancer

ABSTRACT: This study aimed to identify the genetic signatures associated with disease prognosis in bladder cancer. We used 165 primary bladder cancer samples, 23 recurrent non-muscle invasive tumor tissues, 58 normal looking bladder mucosae surrounding cancer and 10 normal bladder mucosae for microarray analysis. Hierarchical clustering was used to stratify the prognosis-related gene classifiers. For validation, real-time reverse-transcriptase polymerase chain reaction (RT-PCR) of top-ranked 14 genes was performed. On unsupervised hierarchical clustering using prognosis related gene-classifier, tumors were divided into 2 groups. The high risk gene signatures had significantly poor prognosis compared to low risk gene signatures (P<0.001 by the log-rank test, respectively). The prognosis-related gene

ORGANISM(S): Homo sapiens

SUBMITTER: Sun-Hee Leem 

PROVIDER: E-GEOD-13507 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress