Codon usage bias is correlated with gene expression levels in the fission yeast Schizosaccharomyces pombe.

ABSTRACT: Usage of synonymous codons represents a characteristic pattern of preference in each organism. It has been inferred that such bias of codon usage has evolved as a result of adaptation for efficient synthesis of proteins. Here we examined synonymous codon usage in genes of the fission yeast Schizosaccharomyces pombe, and compared codon usage bias with expression levels of the gene. In this organism, synonymous codon usage bias was correlated with expression levels of the gene; the bias was most obvious in two-codon amino acids. A similar pattern of the codon usage bias was also observed in Saccharomyces cerevisiae, Arabidopsis thaliana, and Caenorhabditis elegans, but was not obvious in Oryza sativa, Drosophila melanogaster, Takifugu rubripes and Homo sapiens. As codons of the highly expres

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Yuji Chikashige 

PROVIDER: E-GEOD-13554 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress