Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human NIH-3T3 US28-expressing and mock-transfected stablecell lines

ABSTRACT: The human cytomegalovirus (HCMV) encodes the chemokine receptor US28 that exhibits constitutive activity. NIH-3T3 cells stably transfected with US28 present a pro-angiogenic and transformed phenotype both in vitro and in vivo. We used gene expression profiling to determine how US28 constitutive activity modulates expression of genes compared to mock-transfected cells. Experiment Overall Design: We isolated RNA from two different clonal stable cell lines of NIH-3T3 cells transfected either either mock or US28-WT and analysed these 4 RNA samples using Affymetrix mouse genome arrays.

ORGANISM(S): Mus musculus

SUBMITTER: David Maussang 

PROVIDER: E-GEOD-13567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of genes involved in oncogenic signaling in US28-expressing NIH-3T3 cells. In particular, the expression of cyclooxygenase-2 (COX-2), a key mediator of inflammatory diseases and major dete  ...[more]

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