Expression profiling of Clock mutant dorsal skin at telogen

ABSTRACT: Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadian fluctuation, CLOCK-regulated genes are also modulated in phase with the hair growth cycle. During telogen and early anagen, circadian clock genes are prominently expressed in the secondary hair germ, which contains precursor cells for the growing follicle. Analysis of Clock and Bmal1 mutant mice reveals a delay in anagen progression, and the secondary hair germ cells show decreased levels of phosphorylated Rb and lack mitotic cells, suggesting that circadian clock genes regulate anagen progres

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lin 

PROVIDER: E-GEOD-13579 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress