Transcription profiling of Xenopus Dorsal Ventral Pancreatic Bud Comparison

ABSTRACT: During embryogenesis, the pancreas develops from separate dorsal and ventral buds, which fuse to form the mature pancreas. Little is known about the functional differences between these two buds or the relative contribution of cells derived from each portion to the pancreas after fusion. To follow the fate of dorsal or ventral bud derived cells in the pancreas after fusion, we produced chimeric Elas-GFP transgenic/wild type embryos in which either dorsal or ventral pancreatic bud cells expressed GFP. We found that ventral pancreatic cells migrate extensively into the dorsal pancreas after fusion, whereas the converse does not occur. Moreover, we found that annular pancreatic tissue is composed exclusively of ventral pancreas derived cells. To identify ventral pancreas specific genes that m

ORGANISM(S): Xenopus laevis

SUBMITTER: Marko Horb 

PROVIDER: E-GEOD-13603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress