Transcription profiling of mouse model of AML - hierarchical maintenance of MLL myeloid leukemia stem cells

ABSTRACT: Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells; The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional sub-program more akin to that of embryonic stem cells (ESCs) than adult stem cells. The transcription/chromatin regulatory factors Myb, Hmgb3 and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when co-expressed, establishing the

ORGANISM(S): Mus musculus

SUBMITTER: Tim Somervaille 

PROVIDER: E-GEOD-13796 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress