Transcription profiling of rat Dahl salt-sensitive strain development of proteinuria

ABSTRACT: To get more insight in cause and consequences of proteinuria, we studied glomerular gene expression patterns before and after the onset of increased urinary albumin excretion in a proteinuric rat strain. Spontaneously proteinuric Dahl salt-sensitive rats (Dahl SS) were compared to non-proteinuric, spontaneously hypertensive rats (SHR). In Dahl SS, UAE significantly increased starting from week 5 of age. Glomerular RNA profiles of 4- and 6 week-old rats were studied by Affymetrix microarrays. Experiment Overall Design: RNA was extracted from isolated glomeruli of 4- and 6 week-old rats from both strains. At each time point, two rats were used for each strain.

ORGANISM(S): Rattus norvegicus

SUBMITTER: klaas koop 

PROVIDER: E-GEOD-13810 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress