SIV Encephalitis and Uninfected Control: Hippocampus Expression Profiles

ABSTRACT: HIV-associated dementia (HAD) is a syndrome occurring in HIV-infected patients with advanced disease that likely develops as a result of macrophage and microglial activation as well as other immune events triggered by virus in the central nervous system. The most relevant experimental model of HAD, rhesus macaques exhibiting SIV encephalitis (SIVE), closely reproduces the human disease and has been successfully used to advance our understanding of mechanisms underlying HAD. In this study we integrate gene expression data from uninfected and SIV-infected hippocampus with a human protein interaction network and discover modules of genes whose expression patterns distinguish these two states, to facilitate identification of neuronal genes that may contribute to SIVE/HIV cognitive deficits. U

ORGANISM(S): Macaca mulatta

SUBMITTER: Trey Ideker 

PROVIDER: E-GEOD-13824 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress