INTER_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor

ABSTRACT: Wilson and King were among the first to recognize that the extent of phenotypic change between humans and great apes was dissonant with the rate of molecular change. Proteins are virtually identical; cytogenetically there are few rearrangements that distinguish ape-human chromosomes; rates of single-basepair change and retroposon activity have slowed particularly within hominid lineages when compared to rodents or monkeys. Here, we perform a systematic analysis of duplication content of four primate genomes (macaque, orangutan, chimpanzee and human) in an effort to understand the pattern and rates of genomic duplication during hominid evolution. We find that the ancestral branch leading to human and African great apes shows the most significant increase in duplication activity both in term

ORGANISM(S): Pongo abelii

SUBMITTER: M_Francesca Cardone 

PROVIDER: E-GEOD-13884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress