Transcription profiling of human primary gastric tumors (MSI and MSS) and adjacent normal samples

ABSTRACT: Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-3 sigma were significantly more expressed in tumours with than without MSI. A tight immunosurveillance coupled with a functional p53 gene response is consistent with the better prognosis of MSI cancers. Frequent silencing of MLH1 and downregulation of MMR target genes, such as MRE11 and MBD4, charac

ORGANISM(S): Homo sapiens

SUBMITTER: Emanuele de Rinaldis 

PROVIDER: E-GEOD-13911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress