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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human fetal cerebellum, heart, cerebrum, and cerebrum derived astrocyte cell line from trisomy 21 and trisomy 13 samples

ABSTRACT: Gene expression was measured in trisomy 21 and trisomy 13 human fetal samples. For TS21, regions assayed were cerebrum, cerebellum, heart, and cerebrum-derived astrocyte cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Jonathan Pevsner

PROVIDER: E-GEOD-1397 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart.

Mao Rong R Wang Xiaowen X Spitznagel Edward L EL Frelin Laurence P LP Ting Jason C JC Ding Huashi H Kim Jung-whan JW Ruczinski Ingo I Downey Thomas J TJ Pevsner Jonathan J

Genome biology 20051216 13

<h4>Background</h4>Down syndrome, caused by trisomic chromosome 21, is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in chromosome 21 gene expression occur in trisomy 21. However, it is unclear whether the entire transcriptome is disrupted, or whether there is a more restricted increase in the expression of those genes assigned to chromosome 21. Also, the statistical significance of differentially expressed genes in human Down syndro ...[more]

PMID: 16420667

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