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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human renal proximal tubular cell line HK-2 treated with Cyclosporine A timecourse 0, 12, 48 hours

ABSTRACT: Effect of 4.2 micromolar Cyclosporine A on human renal proximal tubular cell line HK-2 over 48 hours

ORGANISM(S): Homo sapiens

SUBMITTER: Craig Slattery

PROVIDER: E-GEOD-1403 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition.

Slattery Craig C Campbell Eric E McMorrow Tara T Ryan Michael P MP

The American journal of pathology 20050801 2

Cyclosporine A, which has been the foremost immunosuppressive agent since the early 1980's, significantly improves the success of organ transplantation. However, common complications of cyclosporine A therapy, such as severe renal tubulointerstitial fibrosis, limit the drug's clinical use. Although the exact mechanisms driving cyclosporine A-induced tubulointerstitial fibrosis remain elusive, we hypothesized that epithelial-mesenchymal transition (EMT) may play a major role. We investigated this ...[more]

PMID: 16049326

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