Dataset Information
Transcription profiling of human SupT1, PBMC or IMR90 cells infected with an HIV-based vector
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Steven Mitchell
PROVIDER: E-GEOD-1407 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.
PLoS biology 20040817 8
The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells. We compared retroviral vectors derived from human immunodeficiency virus (HIV), avian sarcoma-leukosis virus (ASLV), and murine leukemia virus (MLV). Effects of gene activity on integration targeting were assessed by transcriptional profiling of infected cells. Integration by HIV vectors, analyzed in two ...[more]
