Global analysis of alternative splicing regulation by insulin and wingless signalling in Drosophila cells

ABSTRACT: Background: Despite the prevalence and biological relevance of both signalling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signalling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis of changes in alternative splicing using splicing-sensitive microarrays, induced by activation of two distinct signalling pathways, insulin and wingless, in Drosophila cells in culture. Results: Alternative splicing changes induced by insulin affect more than 150 genes and more than 50 genes are regulated by wingless activation. About 40% of the genes showing changes in alternative splicing also show regulation of mRNA levels, suggesting distinct but also significantly overlapping programs of transcriptional and posttranscripti

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Britta Hartmann 

PROVIDER: E-GEOD-14085 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress