Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family

ABSTRACT: The protozoan parasite Theileria parva infects and transforms bovine lymphocytes inducing uncontrolled proliferation. The transforming schizont resides free in the host cell cytoplasm and it is assumed that proteins released from the parasite contribute to host cell transformation and parasite persistence. The identification and characterisation of parasite genes encoding candidate secreted proteins constitutes a first step towards elucidating this complex process. In earlier work, it was shown that the genes encoding subtelomere-encoded variable secreted proteins (SVSPs) are located at the subtelomeres of all four T. parva chromosomes and, with 85 members, form the largest Theileria gene family. The majority of predicted proteins contain signal peptides, suggesting secretion into the

ORGANISM(S): Theileria parva

SUBMITTER: Joachim Müller 

PROVIDER: E-GEOD-14093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress