Analysis of ETS gene expression patterns uncovers novel ETS mediated gene silencing pathways in prostate cancers

ABSTRACT: Deregulated expression of ETS transcription factors with oncogenic and tumor suppressor function occurs frequently in prostate cancer leading to profound alterations of the cancer transcriptome. By integrating genomic and functional studies we identified key targets of the aberrantly expressed ETS factors, ERG and ESE3. Altered expression of ETS factors led to the induction of the polycomb group protein EZH2 and silencing of the tumor suppressor Nkx3.1. Nkx3.1 was controlled by ERG and ESE3 both directly via binding to ETS binding sites in the gene promoter and indirectly via EZH2-induced histone H3K27 methylation. This may represent a general mechanism linking aberrantly expressed ETS with deregulation of epigenetic pathways and global reprogramming of the prostate epithelial cell tran

ORGANISM(S): Homo sapiens

SUBMITTER: Afua Mensah 

PROVIDER: E-GEOD-14206 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress