Transcription profiling of mouse wild type vs Dnmt1 hypomethylated forebrain

ABSTRACT: DNA methylation is a major epigenetic factor regulating genome reprogramming, cell differentiation, developmental gene expression. To understand the role DNA methylation in CNS neurons, we generated conditional Dnmt1 mutant mice that possess ~90% hypomethylated cortical and hippocampal cells in the dorsal forebrain from E13.5 on. The mutant mice were viable with a normal lifespan, but displayed severe neuronal cell death between E14.5 to 3-weeks postnatally. Accompanied with the striking cortical and hippocampal degeneration, adult mutant mice exhibited neurobehavioral defects in learning and memory in adulthood. Unexpectedly, a fraction of Dnmt1-/- cortical neurons survived through postnatal development, so that the residual cortex in mutant mice contained 20-30% of hypomethylated n

ORGANISM(S): Mus musculus

SUBMITTER: Masakazu Namihira 

PROVIDER: E-GEOD-14216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress