Transcription profiling of human CD4+ T cell to identify differences between HIV-1 resistant and HIV-1 susceptible individuals

ABSTRACT: Understanding why some individual resist HIV-1 infection despite continued exposure is an important goal for vaccine development. We compared CD4+ T cell gene expression at baseline in HIV-1 resistant commercial sex-workers from Nairobi, Kenya to HIV-1 high-risk negative (non-resistant) commercial sex-workers using gene expression arrays Experiment Overall Design: CD4+ T cells from both HIV resistant and HIV low-risk negative individuals were isolated from PBMC after 24 hours of culture by negative selection. Total RNA was isolated and gene expression compared using Affymetrix total genome arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Paul McLaren 

PROVIDER: E-GEOD-14278 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress