PRC SiRNA vs scramble transfection in XTC.UC1 cells

ABSTRACT: PGC-1 related coactivator (PRC) shares structural and functional features with PGC-1{alpha}. It regulates several metabolic pathways and mitochondrial biogenesis. Its specific role in the early programming of cell proliferation suggests a finely regulated crosstalk between the mitochondrial functions and the cell cycle status. To explore the PRC-regulated pathways, we used a cell-line model of mitochondrial-rich tumors, presenting an oxidative metabolism and a specific increase in PRC expression. Microarray studies of temporal PRC invalidation in these XTC.UC1 cells were compared to the functional status of the mitochondria as well as to the expression level of genes and proteins involved in the oxidative phosphorylation process. Compared with what was observed for PGC-1{alpha}, we explore

ORGANISM(S): Homo sapiens

SUBMITTER: Frédérique Savagner 

PROVIDER: E-GEOD-14282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress