CEA_SGF:E00010#bcr-abl

ABSTRACT: Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell, characterized by the expression of the Bcr-Abl oncogene by leukemic cells. In order to analyze the molecular pathways modulated by Bcr-Abl, we have previously generated an inducible model of Bcr-Abl expression in the murine Ba/F3 cell line based on the Tet-OFF system. In the present study, through a microarray approach applied to cells grown with (Bcr-Abl-expression OFF) or without (Bcr-Abl-expression ON) doxycycline, a tetracycline analogue, we analyzed the gene expression variations upon Bcr-Abl expression.

ORGANISM(S): Mus musculus

SUBMITTER: Ali G. Turhan 

PROVIDER: E-GEOD-1429 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress