Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain

ABSTRACT: Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes from a CSS using a combination of genetic and genomic approaches as well as by using knowledge about the germ cell tumor disease etiology. We utilized the CSS, 129.MOLF-Chr 19 chromosome substitution strain (or M19), in which males develop germ cell tumors of the testes at an extremely high rate. We are able to identify 3 protein-coding genes and 1 microRNA on chromosome 19 that have previously not been implicated to be testicular tumor susceptibility genes. Our findings suggest that chang

ORGANISM(S): Mus musculus

SUBMITTER: Rui Zhu 

PROVIDER: E-GEOD-14354 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress