Expression data from WT and Aire deficient mTECs

ABSTRACT: Aire is an important transcription regulator that mediates a role in central tolerance via promoting the promiscuous expression of tissue-specific antigens in the thymus. Although several mouse models of Aire-deficiency have been described, none has analysed the phenotype induced by a mutation that emulates the common 13bp deletion in human APECED by disrupting the first PHD domain in exon 8. Aire-deficient mice with a corresponding mutation showed some disturbance of the medullary epithelial compartment, but at the phenotypic level their T cell compartment appeared relatively normal in the thymus and periphery. An increase in the number of activated T cells was evident, and autoantibodies against several organs were detected. At the histological level, lymphocytic infiltration of several

ORGANISM(S): Mus musculus

SUBMITTER: Francois-Xavier Hubert 

PROVIDER: E-GEOD-14365 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress