Genome-wide analysis of expression and DNA methylation at CpG-island-associated sense-antisense transcript loci in mouse

ABSTRACT: Sense-antisense transcript (SAT) pairs are pairs of transcripts that fully or partially overlap but are transcribed in opposite directions. Although SAT expression occurs in various species, most SAT pairs have not been examined in detail. Because our previous studies revealed some tissue specificity in SAT expression, SAT pairs might be involved in cell differentiation and the maintenance of tissue-specific gene expression programs. To analyze such tissue-specific SAT pairs, we assessed the expression profiles of SATs from 12 tissues of normal mice at a genome-wide scale and found that a considerable number of SAT pairs showed expression patterns unique to testis. This finding prompted us to study the relationship between SAT expression pattern and another epigenetic gene regulatory mecha

ORGANISM(S): Mus musculus

SUBMITTER: Yutaka Watanabe 

PROVIDER: E-GEOD-14392 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress