Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Martin Bilban
PROVIDER: E-GEOD-14413 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature immunology 20090121 3
Cytoplasmic DNA triggers activation of the innate immune system. Although 'downstream' signaling components have been characterized, the DNA-sensing components remain elusive. Here we present a systematic proteomics screen for proteins that associate with DNA, 'crossed' to a screen for transcripts induced by interferon-beta, which identified AIM2 as a candidate cytoplasmic DNA sensor. AIM2 showed specificity for double-stranded DNA. It also recruited the inflammasome adaptor ASC and localized to ...[more]