Genome-wide DNA methylation in CEBPA mutant and CEBPA silenced AML

ABSTRACT: Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expression profile but differed in that only half of them harbored mutations of the CEBPA locus, while the rest presented with silencing of this gene and co-expression of certain T cell markers. DNA methylation studies revealed that these two groups of patients could be readily segregated in an unsupervised fashion based on their DNA methylation profiles alone. Furthermore, CEBPA silencing was associated with the presence of an aberrant DNA hypermethylation signature, which was not present in the CE

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Figueroa 

PROVIDER: E-GEOD-14417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress