Transcription profiling of mouse model oradiation induced lung injury reveals Simvastatin attenuates lung vascular leak and inflammation

ABSTRACT: Background: Microvascular injury and increased vascular leakage are prominent features of the radiation-induced lung injury (RILI) which follows cancerâ??associated thoracic irradiation. The mechanisms of RILI are incompletely understood and therapeutic strategies to limit RILI are currently unavailable. We established a murine model of radiation pneumonitis in order to assess mechanism-based therapies for RILI-induced inflammation and vascular barrier dysfunction. Based on prior studies, we investigated the therapeutic potential of simvastatin as a vascular barrier protective agent in RILI. Methods: C57BL6/J mice receiving single dose exposure to 18, 20, 22, or 25 Gy, (n=10/group) were temporally assessed (4-12 weeks) for cellular and biochemical indices of injury present in both bronchoa

ORGANISM(S): Mus musculus

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-14431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress