Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

ABSTRACT: CHD7 is a member of the chromodomain helicase DNA binding domain family of ATP-dependent chromatin remodeling enzymes. De novo mutation of the CHD7 gene is a major cause of CHARGE syndrome, a genetic disease characterized by a complex constellation of birth defects. To gain insight to the function of CHD7, we mapped the distribution of the CHD7 protein on chromatin using the approach of chromatin immunoprecipitation on tiled microarrays (ChIP-chip). These studies were performed in human colorectal carcinoma cells, human neuroblastoma cells, and mouse embryonic stem (ES) cells before and after differentiation into neural precursor cells. The results indicate that CHD7 localizes to discrete locations along chromatin that are specific to each cell type, and that the cell-specific binding o

ORGANISM(S): Mus musculus

SUBMITTER: Mike Schnetz 

PROVIDER: E-GEOD-14460 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress