MiRNA Expression In Maintenance and Differentiation of Human Embryonic Stem Cells

ABSTRACT: Recent advances in the study of human embryonic stem cells (hESCs) and induced-pluripotent stem cells (iPS) highlight their importance as both model systems for basic research and avenues for therapeutic applications. To gain better insight into these cells, a clearer understanding of their molecular properties is crucial. In this study, we analyze changes in the expression profile of microRNAs (miRNAs) and mRNAs in nine different, National Institutes of Health (NIH)-approved hESC lines. By examining both undifferentiated hESCs and cells exposed to an undirected differentiation scheme at early stages, we found those miRNAs and mRNAs enriched in the hESC lines, and those miRNAs and mRNAs initially regulated upon commitment. In comparing these profiles with those of an embryonal carcinom

ORGANISM(S): Homo sapiens

SUBMITTER: Sunny Song 

PROVIDER: E-GEOD-14473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress