Genome wide screen of estrogen receptor α regulated microRNAs reveals a negative autoregulatory feedback loop

ABSTRACT: Estrogen receptor alpha (ERα) is a nuclear receptor linked to progression of the majority of human breast cancers. Following activation ERα regulates the transcription of target genes via DNA binding. Through a genome wide approach we have identified a subset of microRNAs (miRNAs or miRs) modulated by ERα. Among them, miRNAs encoded from 2 paralogous clusters, miR-17-92 and miR-106a-363, were up-regulated. In addition, increased expression of miR-424, miR-542-3p and miR-450, located within the same genomic region and down-regulation of miR-181 family members were observed during the estrogenic response. We observed that ERα alone is sufficient for sustained transcription of miR-17-92 and we show that levels of this cluster increase earlier than miRNAs encoded by it, implicating post-tr

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Thiruchelvam 

PROVIDER: E-GEOD-14685 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress