Involvement of the brain renin-angiotensin system in the effects of maternal separation

ABSTRACT: The postnatal development of the mouse is characterized by a stress hyporesponsive period (SHRP), where basal corticosterone levels are low and responsiveness to mild stressors is reduced. Maternal separation is able to disrupt the SHRP and is widely used to model early trauma. In this study we aimed at identifying of brain systems involved in acute and possible long-term effects of maternal separation. We conducted a microarray-based gene expression analysis in the hypothalamic paraventricular nucleus after maternal separation, which revealed 52 differently regulated genes compared to undisturbed controls, among them are 37 up-regulated and 15 down-regulated genes. One of the prominently unregulated genes, angiotensinogen, was validated using a in-situ hybridization. Angiotensinogen is t

ORGANISM(S): Mus musculus

SUBMITTER: Claudia Liebl 

PROVIDER: E-GEOD-14687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress