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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse cardiac muscle from wild type and mdx mice, 8 week and 10.5 month (Porter lab)

ABSTRACT: Determination of gene expression changes in cardiac muscle of mdx (dystrophin-deficient) mice at postnatal ages 8 weeks and 10.5 months. 3 independent replicates/age/strain.

ORGANISM(S): Mus musculus

SUBMITTER: Henry Kaminski

PROVIDER: E-GEOD-1471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cardiac muscle, comparisons of wild type and mdx mice, 8 week and 10.5 month (Porter lab)

Project description:Determination of gene expression changes in cardiac muscle of mdx (dystrophin-deficient) mice at postnatal ages 8 weeks and 10.5 months. 3 independent replicates/age/strain. Keywords: parallel sample

2004-12-10 | GSE1471 | GEO

Hindlimb muscle, comparison of wild type and mdx mice, 7 to 112 Day (Porter lab)

Project description:Determination of gene expression changes in hindlimb muscle (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112. Keywords: time-course

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Extraocular muscle, comparison of wild type and mdx mice, 14 to 112 Days (Porter lab)

Project description:Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 14, 28, 56, and 112 days. 3 independent replicates/age/strain. Keywords = microarray Keywords = muscle Keywords: time-course

2004-02-04 | GSE1008 | GEO

Diaphram, comparison of wild type and mdx mice, 7 to 112 Days (Porter lab)

Project description:Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004. Keywords = microarray Keywords = muscle Keywords: time-course

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Extraocular, hindlimb, and cardiac muscles, comparison of dko and mdx mice (Porter lab)

Project description:Comparison by expression profiling of tissue from dKO (utrophin/dystrophin-deficient) and MDX mice at 8 weeks of age. Independent triplicate analyses/strain were done for extraocular, hindlimb, and cardiac muscle. Keywords = microarray Keywords = extraocular Keywords: parallel sample

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Transcription profiling of mouse hindlimb muscle, comparison of wild type and mdx mice, 7 to 112 Day

Project description:Determination of gene expression changes in hindlimb muscle (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112.

2007-10-05 | E-GEOD-1025 | biostudies-arrayexpress

Transcription profiling of 16-week-old mdx mouse muscles to characterize transcriptional changes induced by dystrophin deficiency.

Project description:Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-old mouse mdx muscle at a time when the skeletal muscle is avoiding severe dystrophic pathophysiology, despite the absence of a functional dystrophin protein. A number of transcripts whose levels differed between the mdx and human Duchenne muscular dystrophy were noted. A fourfold decrease in myostatin mRNA in the mdx muscle was noted. Differential upregulation of actin-related protein 2/3 (subunit 4), beta-thymosin, calponin, mast cell chymase, and guanidinoacetate methyltransferase mRNA in the more benign mdx was also observed. Transcripts for oxidative and glycolytic enzymes in mdx muscle were not downregulated. These discrepancies could provide candidates for salvage pathways that maintain skeletal muscle integrity in the absence of a functional dystrophin protein in mdx skeletal muscle.

2007-11-06 | E-GEOD-466 | biostudies-arrayexpress

Extraocular and hindlimb muscle, comparison of wild type and mdx mice, 56 days (Porter lab)

Project description:Determination of gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56. 5 independent replicates/muscle group/strain. Keywords: parallel sample

2004-06-15 | GSE1472 | GEO

Transcription profiling of mouse diaphragm, comparison of wild type and mdx mice, 7 to 112 days

Project description:Determination of gene expression changes in diaphragm muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004.

2007-10-05 | E-GEOD-1026 | biostudies-arrayexpress

iTRAQ Protemics of mdx vs. mdx/Actg1-TG mouse skeletal muscle

Project description:Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused by deleterious mutations in the DMD gene, rendering non-functional forms or complete absence of the protein dystrophin. Eccentric contraction-induced force loss is the most robust and reproducible phenotype of dystrophin-deficient skeletal muscle, yet the molecular mechanisms underlying force loss remain obscure. To this end, we utilized the mdx mouse model of DMD, which displays extreme sensitivity to eccentric contractions. An existing mouse line from our lab that overexpresses cytoplasmic gamma-actin specifically in skeletal muscle (mdx/Actg1-TG) was shown to significantly protect mdx muscle against contraction-induced force loss. To understand the mechanism behind this protection, we performed iTRAQ proteomics on mdx/Actg1-TG tibialis anterior (TA) muscle versus non-transgenic littermate controls to identify differentially-expressed proteins that may afford protection upon gamma-actin overexpression.

2018-10-22 | PXD009680 | Pride

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