Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

ABSTRACT: The adult human gut microbial community is typically dominated by two bacterial phyla (divisions), the Firmicutes and the Bacteroidetes. Little is known about the factors that govern the interactions between their members. Here we examine the niches of representatives of both phyla in vivo. Finished genome sequences were generated from E. rectale and E. eligens, which belong to Clostridium Cluster XIVa, one of the most common gut Firmicute clades. Comparison of these and 25 other gut Firmicutes and Bacteroidetes indicated that the former possess smaller genomes and a disproportionately smaller number of glycan-degrading enzymes. Germ-free mice were then colonized with E. rectale and/or a prominent human gut Bacteroidetes, Bacteroides thetaiotaomicron, followed by whole genome transcriptio

ORGANISM(S): Bacteroides thetaiotaomicron

SUBMITTER: Peter Turnbaugh 

PROVIDER: E-GEOD-14737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress