Expression profiling of GIST: CD133 is associated with KIT exon 11 deletion, gastric location and poor prognosis

ABSTRACT: Background & Aims: In gastrointestinal stromal tumors (GIST) KIT exon 11 deletions are associated with poor prognosis. The aim of this study was to determine the gene expression profile of GIST carrying KIT exon 11 deletions and to identify genes associated with poor prognosis. Methods: Expression profiling was performed on 9 tumors with KIT exon 11 deletions and 7 without KIT exon 11 mutations using oligonucleotide microarrays. In addition, gene expression profiles for 35 GISTs were analysed by meta-analysis. Differentially expressed genes were identified and confirmed by qPCR. Expression of CD133 (prominin-1) protein (AC133) was also examined by tissue microarray (TMA) analysis of 204 GISTs from a population-based study in Western Sweden. Survival analysis was performed using Cox regress

ORGANISM(S): Homo sapiens

SUBMITTER: Erik Kristiansson 

PROVIDER: E-GEOD-14755 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress