Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis

ABSTRACT: Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures. Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected to the pilocarpine model of epilepsy at different times during the course of epileptogenesis: 3 days post-SE (3D), 7 days post-SE (7D), and immediately (up to 12h) after the first spontaneous seizure (Chronic). All three pilocarpine subgroups had a corresponding age-matched control group (saline-treated rats), from which normal hippocampi samples were obtained at the same experimental time points. Independent microarray hybridizations were carried out for each sample (n = 5, per experimental gro

ORGANISM(S): Rattus norvegicus

SUBMITTER: Oswaldo Okamoto 

PROVIDER: E-GEOD-14763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress