Gallus gallus utricle striola vs. extra-striola

ABSTRACT: The inner ear utilizes sensory hair cells as mechano-electric transducers for sensing sound and balance. In mammals, these hair cells lack the capacity for regeneration. Unlike mammals, hair cells from non-mammalian vertebrates, such as birds, can be regenerated throughout the life of the organism making them a useful model for studying inner ear genetics pathways. The zinc finger transcription factor GATA3 is required for inner ear development and mutations cause sensory neural deafness in humans. In the avian cochlea GATA3 is expressed throughout the sensory epithelia; however, expression is limited to the striola of the utricle. The striola corresponds to an abrupt change in morphologically distinct hair cell types and a 180° shift in hair cell orientation. We used 3 complimentary appro

ORGANISM(S): Gallus gallus

SUBMITTER: David Alvarado 

PROVIDER: E-GEOD-14783 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress