Transcriptional dosage compensation in heterozygotes for deletions in Drosophila

ABSTRACT: We measured gene expression in two isogenic Drosophila lines heterozygous for long deletions. We find that a majority of genes are at least partially compensated at transcription for ½-fold dosage. The degree of compensation does not vary among functional classes of genes. Compensation for deletions is stronger for highly expressed genes than for genes with low expression level. In contrast, the degree of compensation for duplications observed in Gupta et al, 2006, (J. of Biology 5, 3) data for heterozygotes for a duplication is stronger for weakly expressed genes. Thus, transcriptional compensation appears to be based on general regulatory mechanisms that insure high levels of transcription some genes and low transcription levels of other genes, instead of precise maintenance of a partic

ORGANISM(S): Drosophila melanogaster

SUBMITTER: L Yampolsky 

PROVIDER: E-GEOD-14799 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress