Cadiac GATA-4 overexpression in vivo
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Jaana Rysä
PROVIDER: E-GEOD-14848 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
GATA-4 is an angiogenic survival factor of the infarcted heart.
Rysä Jaana J Tenhunen Olli O Serpi Raisa R Soini Ylermi Y Nemer Mona M Leskinen Hanna H Ruskoaho Heikki H
Circulation. Heart failure 20100303 3
<h4>Background</h4>Recent data suggest that GATA-4 is an antiapoptotic factor required for adaptive responses and a key regulator of hypertrophy and hypertrophy-associated genes in the heart. As a leading cause of chronic heart failure, reversal of postinfarction left ventricular remodeling represents an important target for therapeutic interventions. Here, we studied the role of GATA-4 as a mediator of postinfarction remodeling in rats.<h4>Methods and results</h4>Myocardial infarction, caused b ...[more]
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