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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human CEPH panel members to investigate natural variation in human gene expression

ABSTRACT: We measured the baseline expression levels of genes in members of the CEPH pedigrees using Affymetrix Human Genome Focus Arrays. Arrays were analyzed using MAS 5.0 software (Affymetrix).

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Morley

PROVIDER: E-GEOD-1485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic analysis of genome-wide variation in human gene expression.

Morley Michael M Molony Cliona M CM Weber Teresa M TM Devlin James L JL Ewens Kathryn G KG Spielman Richard S RS Cheung Vivian G VG

Nature 20040721 7001

Natural variation in gene expression is extensive in humans and other organisms, and variation in the baseline expression level of many genes has a heritable component. To localize the genetic determinants of these quantitative traits (expression phenotypes) in humans, we used microarrays to measure gene expression levels and performed genome-wide linkage analysis for expression levels of 3,554 genes in 14 large families. For approximately 1,000 expression phenotypes, there was significant evide ...[more]

PMID: 15269782

Similar Datasets

Natural variation in human gene expression

Project description:We measured the baseline expression levels of genes in members of the CEPH pedigrees using Affymetrix Human Genome Focus Arrays. Arrays were analyzed using MAS 5.0 software (Affymetrix). Keywords = natural variation Keywords = human Keywords: other

2004-08-12 | GSE1485 | GEO

Gene expression levels in immortalized B cells from members of 45 CEPH-Utah pedigrees

Project description:We used microarrays to examine gene expression levels from members of 45 CEPH-Utah pedigrees. Keywords: array-based gene expression

2010-09-21 | GSE16778 | GEO

Transcription profiling of CEPH individuals from the International HapMap Project

Project description:Baseline expression levels of genes in CEPH individuals from the International HapMap Project were measured using the Affymetrix Human Genome Focus Arrays. Arrays were analyzed using MAS 5.0 software (Affymetrix).

2007-06-22 | E-GEOD-2552 | biostudies-arrayexpress

Gene expression levels in immortalized B cells from members of 45 CEPH-Utah pedigrees

Project description:We used microarrays to examine gene expression levels from members of 45 CEPH-Utah pedigrees. Keywords: array-based gene expression We measured gene expression levels in immortalized B cells from members of 45 CEPH-Utah pedigrees. For some cell lines, RNA extracts were hybridized twice, representing technical replicates. For these cell lines, we take the average signal intensity as a measure of relative abundance of a gene. These gene expression levels were then used in genome-wide linkage analyses to identify genetics determinants of gene expression. CEL files were lost for 3 Samples GSM420949, GSM421101, and GSM421103.

2010-09-21 | E-GEOD-16778 | biostudies-arrayexpress

Mapping Determinants of Human Gene Expression by Regional and Whole Genome Association

2005-10-27 | GSE2552 | GEO

Transcription profiling of human irradiated immortalized B cells, lymphoblastoid cells (CEPH) exposed to 10 Gy of ionizing radiation

Project description:We used microarrays to measure the expression levels of genes in irradiated immortalized B cells, lymphoblastoid cells, from members of Centre dEtude du Polymorphisme Humain (CEPH) Utah pedigrees. Data were collected for cells at baseline and 2 hour and 6 hour after exposure to 10 Gy of ionizing radiation (IR). Experiment Overall Design: We used microarrays to measure the expression levels of genes in irradiated immortalized B cells, lymphoblastoid cells, from members of 15 Centre dEtude du Polymorphisme Humain (CEPH) Utah pedigrees (CEPH 1333, 1341, 1346, 1362, 1408, 1416, 1420, 1421, 1423, 1424, 1444, 1447, 1451, 1454, 1582). Expression data was obtained for cell lines derived from 2 parents and 8 children per each family. Cells were irradiated at 10 Gy in a 137Cs irradiator. Cells were harvested prior to radiation and at 2 and 6 hours following exposure to IR.

2009-04-10 | E-GEOD-12626 | biostudies-arrayexpress

Genetic variation in radiation-induced cell death

Project description:We used microarrays to measure the expression levels of genes in irradiated immortalized B cells, lymphoblastoid cells, from members of Centre d'Etude du Polymorphisme Humain (CEPH) Utah pedigrees. Data were collected for cells at baseline and 2 hours and 6 hours after exposure to 10 Gy of ionizing radiation (IR). We measured the expression levels of genes in irradiated immortalized B cells, lymphoblastoid cells, from members of 30 Centre d'Etude du Polymorphisme Humain (CEPH) Utah pedigrees (CEPH 1331, 1332, 1333, 1341, 1344, 1346, 1347, 1349, 1354, 1356, 1357, 1358, 1362, 1408, 1413, 1416, 1418, 1420, 1421, 1423, 1424, 1444, 1447, 1451, 1454, 1456, 1458, 1463, 1477, 1582). Cells were irradiated at 10 Gy in a 137Cs irradiator. Cells were harvested prior to radiation and at 2 and 6 hours following exposure to IR.

2011-08-03 | E-GEOD-26835 | biostudies-arrayexpress

Genetic variation in radiation-induced cell death

2011-08-04 | GSE26835 | GEO

Custom array CGH validation of de novo CNVs in CEU HapMap samples

Project description:This is the validation data for candidate de novo CNV calls made in the CEU Hapmap by Itsara et al., Genome Research 2010. In this study, de novo CNV calls were initially made with Illumina 1M SNP arrays. Validation of CNV calls was performed with Nimblegen custom array CGH using the extended CEPH pedigrees. A truly de novo CNV would be unobserved in the first generation (CEU trio parents), validated in the second generation (CEU trio children), and assuming no selective effects, transmitted to approximately half of the individuals in the third generation. We attempted validation of 4 de novo CNVs in 3 extended CEPH pedigrees: 1358, 1408, and 1459.

2010-09-01 | GSE23575 | GEO

Custom array CGH validation of de novo CNVs in CEU HapMap samples

2010-09-01 | E-GEOD-23575 | biostudies-arrayexpress

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