Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women

ABSTRACT: Advancements in animal models and cell culture techniques have been invaluable in the elucidation of molecular events and mechanisms regulating muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine and validate changes in global gene transcription during immobilization-induced muscle atrophy in humans. Healthy men and women (N=24) were subjected to two weeks of unilateral limb immobilization, with muscle biopsies obtained before, and after 48 hours (48H) and 14 days (14D) of immobilization. Both muscle cross sectional area (~ 5 %) and strength (10-20 %) were significantly reduced in men and women after 14D of immobilization. Micro-array analysis of total RNA extracted from biopsy samples un

ORGANISM(S): Homo sapiens

SUBMITTER: Simon Melov 

PROVIDER: E-GEOD-14901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress