Transcription profiling of rat Lewis strain exposed to behavioural tests for sugar feeding, locomotor activity in a novel field, and acoustic startle reflex, and prepulse inhibition of the acoustic startle reflex to assess relationship between gene expression levels and behaviour in inbred animals

ABSTRACT: Behaviour is derived from complex molecular interactions within the brain, in response to specific environmental stimuli. In some rare cases, the direct causes of behaviour have been attributed to the interactions of a single or small group of gene transcripts and proteins. We conducted two experiments with the hope of defining some of the molecular interactors for four separate behaviours: sugar feeding, locomotor activity in a novel field, and acoustic startle reflex, and prepulse inhibition of the acoustic startle reflex, which have been linked to prefrontal cortex dopaminergic function or as predictors of sensorimotor gating in diseases such as schizophrenia. Rats with high and low response phenotypes were selected to determine the differences between these two extremes of behaviour. F

ORGANISM(S): Rattus norvegicus

SUBMITTER: Paul Boutros 

PROVIDER: E-GEOD-14904 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress