MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer from never-smokers

ABSTRACT: Approximately 15% of lung cancer cases are not associated with smoking and show molecular and clinical characteristics distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are more frequent in never-smoker lung cancers. In this study, microRNA (miRNA) expression profiling of 28 never-smoker lung cancer cases identified aberrantly expressed miRNAs, which were much fewer than in lung cancers of smokers and included miRNAs previously identified (e.g., upregulated miR-21) and unidentified (e.g., downregulated miR-138) in those smoker cases. The changes in expression of some of these miRNAs were more remarkable in cases with EGFR mutations than in those without: the most u

ORGANISM(S): Homo sapiens

SUBMITTER: Shoji Kudoh 

PROVIDER: E-GEOD-14936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress