Transcription profiling of mouse frontal cortex after treatment with zntipsychotic drugs

ABSTRACT: Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorpromazine and thioridazine were selected as typical antipsychotics, and olanzapine and quetiapine as atypical antipsychotics. Since these drugs have similar chemical structures, the effect of the basic structure on gene expression can be eliminated. Cluster analysis of microarray experiments showed thioridazine and olanzapine constituted a robust cluster. K-means clustering separated 4-drug-administered mice into chlorpromazine-quetiapine and thioridazine-olanzapine groups. This classification schem

ORGANISM(S): Mus musculus

SUBMITTER: Shin-ichi Iwata 

PROVIDER: E-GEOD-1501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress