Comparison of gene expression in thyrocytes between wildtype and thyroid-specific IFNg transgenic mice

ABSTRACT: Hürthle cells are found in thyroid tumors and autoimmunity, and have a unique appearance characterized by swollen eosinophilic cytoplasm filled with mitochondria and hyperchromatic nucleus. The pathogenesis of Hürthle cells remains unknown. We have generated transgenic mice expressing IFNg specifically in thyroid gland, and shown they develop changes in the thyroid follicular cell that resemble those of the human Hürthle cell. Transcriptome analysis by serial analysis of gene expression revealed an increased expression of immunoproteasome subunits in transgenic thyrocytes. LMP2, an immunoproteasome subunit also known as PSMB9 or ib1, provided critical for Hürthle cells and hypothyroidism development. Transgenic mice treated with a proteasome inhibitor ameliorated the Hürthle cell phenotyp

ORGANISM(S): Mus musculus

SUBMITTER: Patrizio Caturegli 

PROVIDER: E-GEOD-15114 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress