Transcription profiling of moise mammary tumors in transgenic animals expressing constitutively active and C-terminally truncated variants of STAT5

ABSTRACT: Stat5 is a latent transcription factor that regulates essential growth and survival functions in normal cells. Constitutive activity of Stat5 and the involvement of its C-terminally truncated variant have been implicated in blood cell malignancies and mammary or breast cancer. To distinguish the individual contributions of the Stat5 variants to mammary tumorigenesis, global gene-expression profiling was performed on transgenic STAT5-induced tumors. Experiment Overall Design: Mammary tumors derived from transgenic mice carrying one of two Stat5 variants were collected for RNA extraction and hybridization on Affymetrix GeneChip® Mouse Genome 430A 2.0 array.

ORGANISM(S): Mus musculus

SUBMITTER: Tali Eilon 

PROVIDER: E-GEOD-15119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress