Acid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation

ABSTRACT: Global transcriptional analysis of acid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation pH is a major environmental factor that regulates gene expression in many bacteria. Streptococcus mutans in dental biofilms is regularly exposed to cycles of acidic pH during the ingestion of fermentable dietary carbohydrates. The ability of S. mutans to tolerate low pH is crucial for its virulence and the pathogenesis in dental caries. To better understand its acid tolerance mechanisms, we used DNA microarray to perform genome-wide transcriptional analysis of S. mutans in response to acidic pH. The results showed that adaptation of S. mutans to pH 5.5 for 2 hrs induced differential expression of nearly 14% of genes in the genome, including 169 up-reg

ORGANISM(S): Streptococcus mutans

SUBMITTER: Yung-Hua Li 

PROVIDER: E-GEOD-15125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress